Software-only startups in the US and Israel
Pre-seed, Seed, and Series A
Society is experiencing dramatic disruptions in many markets and geographies. Talented entrepreneurs are nimbler and better suited than incumbents to take advantage of rapidly changing market conditions.
Our founders target emerging opportunities and design their ventures with the rules of new paradigms in mind.
Founder & Managing Director
As the Founder and decade-long CEO of MassChallenge, John is obsessed with entrepreneurship and has worked with thousands of startups since 2010. MassChallenge is the most-startup-friendly and largest startup accelerator on the planet and has graduated over 3,000 startups which have cumulatively generated billions of dollars of revenue and have created over 200,000 jobs.
While launching and running MassChallenge, John generated a vast network of new and established founders, corporate partners, investors, and innovation talent. Furthermore, John gained unrivaled experience working to support startups as an advisor and connector, learning which teams, models, and partners create sustainable success most consistently. John left MassChallenge in 2019 to launch Two Lanterns in 2020.
John holds a BA from Bowdoin College, an MBA from the MIT Sloan School of Management, an Honorary Doctorate from Suffolk University, and certificates for Leadership and Innovation from Harvard, Yale, and Princeton.
Michal Gilon-Yanai has been the founder and director of multiple entrepreneurship programs in the US and in Israel. She founded the MBA Innovation & Entrepreneurship track at IDC, directed two programs at MIT’s entrepreneurship center and, most recently, founded and led the Biomedical Entrepreneurship Program at the NYU school of medicine. Through this work, she developed a keen understanding of technology and science commercialization and supported dozens of innovators and entrepreneurs over the course of two decades. Michal began her career at a healthcare IT startup where she filled several roles and served as a member of the company’s management team.
Michal also played a critical role in launching the MassChallenge Israel program, joining its advisory board for several years. She has outstanding access to deal flow, and contributes deep startup experience to Two Lanterns. Michal served in the IDF Intelligence corps, received computer science and law degrees from Tel Aviv University, and earned her MBA from the MIT Sloan School of Management in 2007. She joined Two Lanterns Venture Partners in 2020.
Lily Toto is a startup enthusiast with a strong desire to support entrepreneurs. She brings a wealth of experience from her time in strategy consulting at L.E.K. Consulting, where she worked on projects spanning the life sciences, consumer retail, and technology sectors.
In addition, Lily has gained invaluable experience working for various early-stage software startups, where her work spanned marketing, business development, and strategic operations. Her combined experience in consulting and start-ups has given her the ability to understand complex business challenges and identify growth opportunities.
Lily received a BA in Economics and Government from Georgetown University, where she served as the CEO of Georgetown Collegiate Investors, an undergraduate equity investment fund. She joined Two Lanterns Venture Partners as an Associate in 2023.
Founder Cascade Communications, Sycamore Networks, etc
Serial mentor, investor, philanthropist
Life-member of the MIT Corporation
Founding Board Member, MassChallenge
PhD Queens University
B.Tech. IIT Madras
Israeli Super Angel with extensive experience as an investor (over 200 investments) and investment advisor
Transaction manager for some of Israel’s most recognized exits, managing each from inception to exit
Pivotal advisor for creation of MassChallenge Israel
MBA Tel Aviv University
BS EE/CS Technion University
Managing General Partner at Mission BioCapital
Founder and Director, LabCentral
Life Sciences Champion, MassChallenge
President and CEO, Cequent Pharmaceuticals
General Partner Ampersand Capital Partners
BS, MS Columbia University
Executive Fellow in Entrepreneurship at
the Rock Center, Harvard Business School
Executive Partner of Blue Cloud Ventures,
a growth equity fund based in NYC
Entrepreneur in life science and healthcare
Active early-stage investor; member of
TiE Angels, TBD Angels, and Sky Ventures
PhD in Electrical and Computer Engineering with a focus on medical imaging
The DriveU.auto Teleoperation Connectivity Platform enables safe teleoperation of robots and autonomous vehicles using cellular bonding and dynamic encoding. The platform is already deployed and in use on public roads, across multiple use cases, including delivery robots, autonomous trucks, shuttles, robotaxis and more.
StrongArm Technologies (SAT) is an Industry 4.0 platform that delivers a technology solution to keep industrial workers protected and productive, and has reduced injuries by over 40% YoY for major enterprises including Walmart and Toyota. The solution includes a wearable device with multiple sensors (including COVID-related functionality via worker proximity), a smart dock with a touch-screen that delivers customized micro-training, and a software platform that shares actionable insights with management.
Lex is creating a securities marketplace for fractionalized commercial real estate investments. LEX sources investment opportunities in Core and Core+ assets, and structures and prices them for an offering using the RegA Tier 2 exemption. LEX then facilitates secondary trading on an Alternative Trading System using NASDAQ technology.
ShipIn delivers visibility, productivity and safety to maritime transport, the backbone of global trade. ShipIn provides ship owners and managers with advanced fleet management solutions, improving operations and financial performance across global fleets. The maritime industry is embarking on an extensive digital transformation. ShipInSystems is at the forefront of smart shipping development, posed to deliver significant value to industry stakeholders.
Akooda is developing an AI platform to help distributed teams understand and optimize how they communicate with each other to improve performance and productivity. Akooda is led by Yuval Gonczarowski, formerly CTO at ClimaCell ($100m+ in funding), McKinsey, Apple, Intel, and 8200-IDF.
Loora is developing an affordable and always available AI language tutor. Necessary technology leaps to enable AI-powered conversation have only just occurred. Loora will offer an AI tutor that is always available and 10x more affordable than a human tutor.
Array Insights provides a digital rights management solution for hospitals to manage and audit access to patient data in a secure manner. Array Insight's technology enables hospitals to maintain control of research collaborations to fully protect the privacy of their patients and the security of their patient records.
As the solution for navigating mortality, Cake uses data to match consumers with the right products for their end-of-life needs. Cake is the first stop for consumers and is the largest in the industry, on track to dominate an overlooked trillion-dollar industry. Founders are graduates of MIT and Harvard and have deep experience in healthcare and digital marketing. The CMO was an early employee at TripAdvisor.
TheXPlace is a Marketplace for the $217B Video Games industry, connecting Game Development Companies with the talent to get the next “hit” produced, and connecting video gaming professionals (soloists, contracting companies, studios and agencies) with work. Founder is Technion & MIT grad with 20+ years' experience and extensive contacts in the gaming industry.
Knox is the first automated wealth advisor and management company for property investors delivering superior investment outcomes end-to-end – from payments to banking, leasing to insurance, financing to tax, vacancy avoidance to maintenance. Knox is democratizing access to preferred rates of return via the $1.25T/yr residential investment property market. Founder sold prior real estate startup to Private Equity firm.
Co-Investors include G20, Pillar, TBD Angels, and Greycroft.
Because Marketing helps bridge off-site data into a personalized on-site experience for the $1.3T e-commerce industry. Through an intelligent data engine, user-defined automation, and A/B testing, they're helping growing Shopify businesses to optimize conversion of site visitors at scale. Founder won Young Entrepreneur of the Year Award in 2015.
Gravity AI is a marketplace for enterprise-ready AI. Engineers can browse 3rd party AI technologies that are secure, vetted for compliance, and automatically standardized in a custom container for easy, low-code implementation, all through a single procurement process that vastly increases speed to market for product teams.
Cooklist is an all-in-one grocery app for consumers to manage the full cycle of buying and using groceries efficiently. It is the first and only service that connects directly to grocery store accounts so consumers can automatically track the food they buy, keep track of expirations, find recipes they can cook right now, create meal plans and shopping lists, and send orders to local stores for pickup or delivery. The app works with over 80% of the grocery stores in the US and millions of recipes.
Voyantis is the first no-code growth platform, leveraging ML & AI to optimize user acquisition for B2C companies. Voyantis uses machine learning to predict each user’s future LTV, conversion, retention and virality, enabling top brands to optimize user acquisition based on the true value of users. Customers have experienced Return On Ad Spend uplift of more than 200%.
Cupixel is an augmented reality platform aspiring to be the leading arts and crafts brand for creative experiences. Cupixel enables anyone to draw any photo in any style. Users can create experiences by drawing together (with or without expert guidance) and can share their finished work and time-lapse creation videos via other social media.
Axiom Health is a data technology company that helps MedTech commercial teams get evidence-based, data-driven answers to their daily questions. Axiom's platform organizes, enriches, and makes predictions with data to help customers learn from the past, understand the present, and predict the future state of the MedTech market, in minutes. With Axiom, getting trusted answers to MedTech questions is easier, faster, and more accurate.
Surround is reinventing insurance for modern life. The Managing General Agency (MGA) helps consumers in their 20s and 30s get started with simple and accessible insurance products designed around mobility, shelter, and work.
Koffie Insurance is a digital insurer purpose-built for the next generation of trucking and transportation and is the first insurtech to integrate safety technology into underwriting, pricing and loss control. Using real time data and machine learning models, Koffie delivers instant and tailored policies to modern truckers that invest in safety, rewarding them with lower premiums than traditional insurers.
SEMPRE offers a new class of micro edge datacenters that ensure access to data – anytime, anywhere, even in catastrophic conditions. SEMPRE offers high-performance edge computing and diverse, secure communications, including 5G, all in a tamper-resistant, EMP-hardened enclosure.
Trove Health is building the world’s largest longitudinal, consented database of patients and their health information. Trove is used to expedite clinical research, collect targeted patient reported outcomes, create longitudinal visibility into patients' health histories, and conduct targeted marketing campaigns.
VoiceScript, Inc. is a leading supplier of legal technology-based SaaS solutions designed to modernize the court reporting and legal industries. VoiceScript solutions enable court reporting agencies and independent service providers to deliver best-in-class court reporting services while also significantly reducing production costs and delivery times for legal transcripts.
Fermata Discovery creates streamlined AI tools that accelerate the investigation processes of private and public sector agencies. Its flagship product, VIXN, is a multifunctional intelligence management and visualization platform that can adapt to any type of case. Fermata's suite of proprietary and OSINT search tools automate investigators’ time-consuming processes to expose deep data insights.
SoHookd is a wellness hub for enterprises that helps healthcare carriers (payers) retain, support, and improve wellness for their employer group stakeholders by offering holistic and turnkey solutions. SoHookd helps employers bring leading and innovative wellness offerings to employees through a marketplace that lets them choose what is most beneficial to them individually.
dataplor uses AI/ML and human capital to offer the highest quality location data across the globe. Customers ranging from the Fortune 500 to international startups rely on dataplor's accurate location data to drive outcomes in the $200B+ geospatial market.
Narrable is the modern platform for healthcare at home. Narrable’s intelligent clinical solutions and automated financial systems save providers up to 60% in inefficiencies per year. Home health providers across the nation choose Narrable to deliver on their promise to patients and families.
Core team hails from Workday & Gusto; Co-investors include Flare Capital, Bienville Capital, and Washington Creek Capital.
basys.ai uses an AI-based platform to automate the process of prior authorization and utilization management, improving costs for health plans/payers. By automating the process of encoding/digitizing payer policies using machine learning, they reduce piloting timelines by up to 9 months.
ReturnGO’s innovative technology is at the forefront of the evolving returns management market as the first open post-purchase platform for sustainable eCommerce, helping businesses increase profits while reducing waste.
Co-investors include GoodCompany VC, TPY Capital, Cresson, Aristagora, and more.
Stockpress is an easy-to-use media management platform that gives teams and external partners one centralized workspace to securely collaborate on, organize, and share media. Stockpress combines the folder structure from traditional file management with digital asset management features such as AI and custom file tagging, file versioning, duplicate file detection, robust permission structures, and more.
Co-investors include Alumni Ventures and Stage 2 Capital.